The Use of Intact Fish Skin as a Novel Treatment Method for Deep Dermal Burns Following Enzymatic Debridement: A Retrospective Case-Control Study

Background: The optimal therapy for deep burn wounds is based on the early debridement of necrotic tissue followed by wound coverage to avoid a systemic inflammatory response and optimize scar-free healing. outcomes are affected available resources underlying patient factors, which represent challenges in care suboptimal outcomes. In this study, we aimed determine burn-wound management using enzymatic (NexoBrid™, MediWound Germany GmbH, Rüsselsheim, Germany) intact fish skin (Kerecis® Omega3 Wound, Isafjordur, Iceland). Methods: retrospective case series, 12 patients with superficial or dermal were treated skin, Suprathel® (PolyMedics Innovations Denkendorf, Germany), split-thickness graft (STSG). Patients’ regarding healing scar quality collected objectively subjectively months after injury. Results: Wounds demonstrated accelerated healing, significantly higher water-storage capacity, better pain relief. Furthermore, improved functional cosmetic outcomes, such as elasticity, thickness, pigmentation, demonstrated. itch expressed POSAS scores (Patient Observer Scar Assessment Scale) decreased compared those managed an STSG Suprathel. Importantly, skin-treated had sebum production elasticity than Suprathel but showed no significant superiority STSG-treated wounds. Conclusions: Enzymatic combination grafts resulted faster aesthetic treatment.